Genome-scale modeling for metabolic engineering
نویسندگان
چکیده
منابع مشابه
Genome scale metabolic modeling of the riboflavin overproducer Ashbya gossypii.
Ashbya gossypii is a filamentous fungus that naturally overproduces riboflavin, or vitamin B2. Advances in genetic and metabolic engineering of A. gossypii have permitted the switch from industrial chemical synthesis to the current biotechnological production of this vitamin. Additionally, A. gossypii is a model organism with one of the smallest eukaryote genomes being phylogenetically close to...
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During the last decade, models have been developed to characterize cellular metabolism at the level of an entire metabolic network. The main concept that underlies whole-network metabolic modeling is the identification and mathematical definition of constraints. Here, we review large-scale metabolic network modeling, in particular, stoichiometric- and constraint-based approaches. Although many ...
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ژورنال
عنوان ژورنال: Journal of Industrial Microbiology and Biotechnology
سال: 2015
ISSN: 1476-5535,1367-5435
DOI: 10.1007/s10295-014-1576-3